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Formulation Development

Sharp help you overcome development challenges, keep costs down and accelerate your time to market. We’ll work with you to develop a reliable formulation that gives optimal clinical outcomes and can be easily reproduced on a large scale, with excellent stability.

Getting the very best clinical and commercial value from your product means making sure it’s manufactured in a viable, efficient way and its benefits are delivered quickly and effectively.

Our experienced team of formulation scientists works with state-of-the-art equipment and laboratory facilities, creating innovative formulations that work incredibly effectively with your active pharmaceutical ingredient (API).

Pre-formulation services:

  • Chemical compatibility and reactivity to packaging substrates.
  • Physical properties and product characterisation.
  • Accelerated degradation.
  • (API)-excipient interaction studies.
  • pKa determination.
  • Hygroscopicity studies.
  • Photostability of API.
  • Prototype evaluations.
  • Reverse engineering.

Formulation development services:

  • Phase I-IV formulation development and reformulations.
  • Determining blending times for tabletting, encapsulation and analysis of characteristics (blending time, bulk density, content uniformity and flow characteristics).
  • Over-encapsulation and comparator product blinding.
  • Developing matching placebo products and comparator supplies.
  • Developing ethical, over-the-counter products, including tablets (immediate and controlled release), powders, liquids, suspensions, emulsions, creams, ointments and lotions.
  • Developing line extensions in the above dosage forms.

Technical services:

  • Troubleshooting commercial products.
  • Formulation optimisation and evaluation of new raw materials in existing products.
  • Technical transfer of products from R&D to production facilities.
  • Process optimisation and scale-up and assessment of current products.
  • Modernising existing manufacturing and clinical supplies processes.

Talk to our expert team today about your formulation development and manufacturing needs.

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