We developed a new sterile filling process designed to reduce product loss for high-value drug product candidates. The process is intended for customers that have limited drug product and need to conserve every drop. It is also well suited for drug products with very small volume filling needs where precision is important. Filling is entirely isolator-based, easy to operate, and has demonstrated superior repeatability and accuracy.
| Scale | Container Type | Lyophilization | Pump |
|---|---|---|---|
| Up to 1.1L batch/run | Vials | No | None – Pressure & Actuator |
Advantages
- 100% Isolator-based
- Very little volume loss
- Non-destructive weight checks
- Requires little training (no pipetting)
- Extremely accurate & repeatable
- Ideal for sheer-sensitive products
- Works well for viscous solutions
- Quick manual filling
Limitations
- Vial filling only
- No nitrogen headspace option
See how this process works
Our unique low loss fill sterile vial filling service uses low pressure and a highly accurate actuator to set the fill volume. There is no hand-pipetting involved. The process is entirely isolator-based to offer the best sterility assurance.
